Functional Exploration and Neuromodulation of the CNS

Functional Exploration and Neuromodulation of the CNS. Grupo FENNSI

 

Principal investigator: Dr. Antonio Oliviero

E-mail: antonioo@sescam.jccm.es

 

               

We are a group of clinical and basic researchers whose main interest is the study and research of physiology, as well as the clinical application of non-invasive techniques of neuromodulation of the nervous system. In addition, we perform functional evaluations of the central and peripheral nervous system in neurological disorders, such as spinal cord injury. All this with the ultimate goal of translation to a clinical setting. The laboratory has all the necessary equipment to carry out these approaches.

 

 

 

Personnel

 

Antonio Oliviero: laboratory chief. Chief of the Neurology area of HNP. PhD Neuroscience.

 

Ángela Brocalero Camacho: physician of the Neurology area of HNP. PhD Neuroscience.

 

Vanesa Soto León: postdoctoral researcher. – telecommunications engineer. PhD Neuroscience.

 

Yolanda Pérez Borrego: postdoctoral researcher – neuropsychologist. PhD. Experimental Biomedicine.

 

Mª Asunción de la Barreda Manso: postdoctoral researcher – study coordinator. PhD. Biology.

 

Sara Fernández Canosa: predoctoral reseacher – physiotherapist. MsC. Neurology physiotherapy.

 

Eva Díez Rodríguez: predoctoral reseacher – neuropsychologist. MsC. Neuroscience.

 

Fátima Villamayor Vega: laboratory technician – occupational therapist. MsC. Motor Neurocontrol.

 

 

 

 

Research lines

 

- Physiological evaluation and development of NIBS techniques, performing non-invasive stimulation of the cerebral cortex by repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and transcranial static magnetic field stimulation (tSMS).

 

- Study by means of functional magnetic resonance imaging.

 

- Application of neuromodulation techniques (tDCS, rTMS, tSMS) in neurodegenerative pathologies, chronic pain, spinal cord injury, migraines and fatigue.

 

- Study of clinical and neurophysiological aspects of spinal cord injury in humans.

 

- Development of assessment protocols for patients with spinal cord injury.

 

- Clinical trials on patients with spinal cord injury or patients with drug-resistant chronic pain.

 

- Study of the neurophysiological mechanisms involved in central fatigue (in healthy volunteers, in patients with spinal cord injury and in patients with multiple sclerosis).

 

- Treatment of central fatigue in spinal cord injury using cannabinoid receptor antagonists/inverse agonists. Carried out in collaboration with the Molecular Neuroprotection Group (GNPM) of the HNP. This project is financed through an agreement with the company Samos Medical Enterprise S.L.U.

 

- Clinical trials in spinal cord injured patients with fatigue.

 

 

 

Projects

               

• Human-robot sensorimotor augmentation - wearable sensorimotor interfaces and supernumerary robotic limbs for humans with upper-limb disabilities. IP. AO. ISCIII (HARIA-101070292).

 

• Rimonabant y Enfermedad de Parkinson: efectos sobre síntomas motores. IP: AO.  Junta de Comunidades de Castilla La Mancha  (SBPLY721/180501/000141).

 

• Síndrome de fatiga post  COVID-19: alteraciones de la excitabilidad del sistema motor y uso del Rimonabant como tratamiento (RIMOCOVID). IP: AO. Plan Nacional_Ministerio de Ciencia e Innovación (PID2020-117617-RB).

 

• Rimonabant for improving walking abilities in spinal cord injury. IP: AO. Instituto de Salud Carlos III (ICI20/00075).

 

• Efectos de los campos magnéticos estáticos sobre el cerebro: estudio de los mecanismos. IP: VSL. Fundación Ramón Areces (CIVP20A6617).

 

• Estimulación cerebral - Desarrollo participativo de un Código de Conducta para la Unión Europea. IP: AO. ERA-NET-NEURON (AC20/00074).

 

• European Training on innovative Restorative Protocols for clinical and technological changeable. IP: AO. Comisión Europea (KA202-D7D43DC7).

 

• Detección domiciliaria de neumonía asociada a COVID-19 utilizando una APP y un algoritmo de inteligencia artificial. IP: AO. Fundación GlobalCaja (AyudasInvestigación_2020).

 

• Effects of CB1 antagonist/inverse agonist (Rimonabant) on walking abilities and endurance in incomplete traumatic SCI: a proof of principle study. IP: AO. International Foundation for Research in Paraplegia (181).

 

• Proyecto. IP: AO. Red Española De Estimulacion Cerebral.

 

• Etimulacion Cerebral No Invasiva Con Campos Magneticos Estaticos: Transferiendo La Estimulacion Transcraneal Desde El Laboratorio Al Paciente. IP: AO. Ministerio De Economía Y Competitividad (SAF2016-80647-R).

 

 

Papers

 

• Onate-Figuérez A, Soto-León V, Avendaño-Coy J, Mordillo-Mateos L, Pérez-Borrego YA, Redondo-Galán C, Arias P, Oliviero A. Hand Motor Fatigability Induced by a Simple Isometric Task in Spinal Cord Injury. J Clin Med. 2022 Aug 30;11(17):5108. doi: 10.3390/jcm11175108. PMID: 36079035; PMCID: PMC9457081.

 

• Onate-Figuérez A, Avendaño-Coy J, Fernández-Canosa S, Soto-León V, López-Molina MI, Oliviero A. Factors Associated With Fatigue in People With Spinal Cord Injury: A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2022 Aug 12:S0003-9993(22)00574-3. doi: 10.1016/j.apmr.2022.07.017. Epub ahead of print. PMID: 35964699.

 

• Soto-León V, Torres-Llacsa M, Mordillo-Mateos L, Carrasco-López C, Pineda-Pardo JA, Velasco AI, Abad-Toribio L, Tornero J, Foffani G, Strange BA, Oliviero A. Static magnetic field stimulation over motor cortex modulates resting functional connectivity in humans. Sci Rep. 2022 May 12;12(1):7834. doi: 10.1038/s41598-022-11859-5. PMID: 35551490; PMCID: PMC9098424.

 

• Esclarin-Ruz A, Rodríguez-Carrión I, Ceruelo-Abajo S, Palazón-Garcia R, Ayuga-Loro F, Carrasco-Lopez C, Alcobendas-Maestro M, Casado-Lopez RM, Talavera-Diaz F, Soto-León V, Campolo M, Romero-Ganuza FJ, Florensa-Vila J, Garcia-Marco D, Rotondi M, Oliviero A. Phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone treatment in incomplete chronic traumatic spinal cord injury. Spinal Cord. 2021 Aug;59(8):917-924. doi: 10.1038/s41393-021-00662-0. Epub 2021 Jul 5. PMID: 34226654.

 

• Soto-Leon V, Alonso-Bonilla C, Peinado-Palomino D, Torres-Pareja M, Mendoza-Laiz N, Mordillo-Mateos L, Onate-Figuerez A, Arias P, Aguilar J, Oliviero A. Effects of fatigue induced by repetitive movements and isometric tasks on reaction time. Hum Mov Sci. 2020 Oct;73:102679. doi: 10.1016/j.humov.2020.102679. Epub 2020 Sep 25. PMID: 32980590.

 

• Hernando A, Galvez F, García MA, Soto-León V, Alonso-Bonilla C, Aguilar J, Oliviero A. Effects of Moderate Static Magnetic Field on Neural Systems Is a Non-invasive Mechanical Stimulation of the Brain Possible Theoretically? Front Neurosci. 2020 May 19;14:419. doi: 10.3389/fnins.2020.00419. PMID: 32508563; PMCID: PMC7248270.

 

• Brocalero-Camacho A, Pérez-Borrego YA, Soto-León V, Rodriguez-Matas MJ, Foffani G, Oliviero A. Effects of COVID-19 lockdown on chronic drug-resistant pain patients treated using brain stimulation approaches. Brain Stimul. 2020 Jul-Aug;13(4):1089-1090. doi: 10.1016/j.brs.2020.05.003. Epub 2020 May 8. PMID: 32389838; PMCID: PMC7206438.

 

• Mordillo-Mateos L, Soto-Leon V, Torres-Pareja M, Peinado-Palomino D, Mendoza-Laiz N, Alonso-Bonilla C, Dileone M, Rotondi M, Aguilar J, Oliviero A. Fatigue in Multiple Sclerosis: General and Perceived Fatigue Does Not Depend on Corticospinal Tract Dysfunction. Front Neurol. 2019 Apr 9;10:339. doi: 10.3389/fneur.2019.00339. PMID: 31024433; PMCID: PMC6465550.

 

• Lozano-Soto E, Soto-León V, Sabbarese S, Ruiz-Alvarez L, Sanchez-Del-Rio M, Aguilar J, Strange BA, Foffani G, Oliviero A. Transcranial static magnetic field stimulation (tSMS) of the visual cortex decreases experimental photophobia. Cephalalgia. 2018 Jul;38(8):1493-1497. doi: 10.1177/0333102417736899. Epub 2017 Oct 11. PMID: 29020806.

 

• Cudeiro-Blanco J, Onate-Figuérez A, Soto-León V, Avendaño-Coy J, Mordillo-Mateos L, Brocalero-Camacho A, Esclarin-Ruz A, Rotondi M, Aguilar J, Arias P, Oliviero A. Prevalence of Fatigue and Associated Factors in a Spinal Cord Injury Population: Data from an Internet-Based and Face-to-Face Surveys. J Neurotrauma. 2017 Aug 1;34(15):2335-2341. doi: 10.1089/neu.2016.4950. Epub 2017 Jun 28. PMID: 28569601.

 

• Mordillo-Mateos L, Dileone M, Soto-León V, Brocalero-Camacho A, Pérez-Borrego YA, Onate-Figuerez A, Aguilar J, Oliviero A. Effects of transcranial direct current stimulation on temperature and pain perception. Sci Rep. 2017 Jun 7;7(1):2946. doi: 10.1038/s41598-017-03173-2. PMID: 28592857; PMCID: PMC5462761.

 

• Carrasco-López C, Soto-León V, Céspedes V, Profice P, Strange BA, Foffani G, Oliviero A. Static Magnetic Field Stimulation over Parietal Cortex Enhances Somatosensory Detection in Humans. J Neurosci. 2017 Apr 5;37(14):3840-3847. doi: 10.1523/JNEUROSCI.2123-16.2017. Epub 2017 Mar 9. PMID: 28280254; PMCID: PMC6596712.

 

• Lozano-Soto E, Soto-León V, Sabbarese S, Ruiz-Alvarez L, Sanchez-Del-Rio M, Aguilar J, Strange BA, Foffani G, Oliviero A. Transcranial static magnetic field stimulation (tSMS) of the visual cortex decreases experimental photophobia. Cephalalgia. 2018 Jul;38(8):1493-1497. doi: 10.1177/0333102417736899. Epub 2017 Oct 11. PMID: 29020806.

 

 

Patents

 

• Dispositivo para estimulación del sistema nervioso por medio de campo magnético estático y uso de dicho dispositivo.

 

• Use of antagonist and/or inverse agonists of CB1 receptors for preparing medicaments for treating postviral fatigue symdrome.

 

• Uso de antagonistas y/o agonistas inversos de los receptores CB1 para la preparación de medicamentos que incrementen la excitabilidad de las motoneuronas.