Research Magnetic Resonance

Marina Benito, Research Magnetic Resonance

Research Magnetic Resonance

 

Person in charge: Dra. Marina Benito

E-mail: mbenitov@sescam.jccm.es

 

Magnetic Resonance Imaging is a noninvasive technique that allows you to obtain images using the intrinsic contrast of the proton (1H) excitation within a static magnetic field. It has a number of advantages over others: (1) The main one is that it does not use ionizing radiation, so it is a non-invasive technique; (2) slices or planes can be acquired in any direction; (3) very good resolution images are obtained. However, one of the main drawbacks is that long acquisition times are required.

 

The Research Magnetic Resonance Laboratory of the Hospital Nacional de Parapléjicos is destined for studies in both rat and mouse mainly, although studies in small cats and / or rabbits could also be carried out.

 

The availability of the mouse brain cryoprobe gives this laboratory a significant advantage over other equipment nationwide since there are no many facilities with similar characteristics.

 

The laboratory offers service to the different research groups of the Hospital as well as external groups and private companies.

 

 

Selected publications

 

- Domínguez-Bajo A, González-Mayorga A, Guerrero CR, Palomares FJ, García R, López-Dolado E, Serrano MC. Myelinated axons and functional blood vessels populate mechanically compliant rGO foams in chronic cervical hemisected rats. Biomaterials. 2019 Feb;192:461-474. doi: 10.1016/j.biomaterials.2018.11.024. Epub 2018 Nov 19. PMID: 30502723.

 

- Villa-Valverde P, Rodríguez I, Padró D, Benito M, Garrido-Salmon CE, Ruiz-Cabello J. A dual 1H/19F birdcagecoilforsmallanimals at 7 T MRI. MAGMA. 2019 Feb;32(1):79-87. doi: 10.1007/s10334-018-00733-z. Epub 2019 Feb 16. PMID: 30778714.

 

- Pellico J, Fernández-Barahona I, Benito M, Gaitán-Simón Á, Gutiérrez L, Ruiz-Cabello J, Herranz F. Unambiguousdetection of atherosclerosisusingbioorthogonalnanomaterials. Nanomedicine. 2019 Apr;17:26-35. doi: 10.1016/j.nano.2018.12.015. Epub 2019 Jan 14. PMID: 30654185.

 

- Aguilera, Y.; Mellado-Damas, N.; Olmedo-Moreno, L.; López, V.; Panadero-Morón, C.; Benito, M.; Guerrero-Cázares, H.; Márquez-Vega, C.; Martín-Montalvo, A.; Capilla-González, V. Preclinical Safety Evaluation of IntranasallyDelivered Human MesenchymalStemCells in JuvenileMice. Cancers 2021, 13,1169. https://doi.org/10.3390/cancers13051169.

 

 

Equipment

 

  • Bruker Biospec 70/30 with three gradient systems: BGA 6S (1000mT/m), BGA 12S HP (440mT/m) y BGA 20S HP (200mT/m)
  • Mouse brain MRI Cryoprobe
  • Volume coils for rats, mice and small cats/rabbits
  • Rat brain phase arraycoil
  • Cardiac and Spinal Cord MRI phase array coil
  • 1H/31P surface coil
  • Two Linux workstation for acquiring and processing with Paravision 6.0.1
  • Cardiac and respiratory monitoring system
  • Water heating system
  • Gas anaesthesia system
  • In addition, it has an animal room attached to the laboratory

 

 

Services offered

 

  • Anatomic and morphologic MRI
  • Diffusion MRI and Tractography
  • Angiography MRI
  • Localized spectroscopy 1H
  • Heteronuclear spectroscopy 1H/31P
  • Cardiac MRI
  • Biological samples MRI
  • Contrast agents administration for visualization and characterization via MRI
  • Image and Spectra processing

 

 

Image Gallery

 

bruker_7.jpg

 

 

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Please, click here to know more about our fees

 

 

- Bookings will be made through email and with a minimum of 2 weeks in advance.

- Send the request form completed. REQUEST

- Provide the necessary documentation for the animal´s admission.

 

 

Contact person and bookings

 

Dra. Marina Benito Vicente

Research MR laboratory

Edf. Investigación Planta -1

Hospital Nacional de Parapléjicos

Finca la Peraleda s/n

45071 Toledo

España

e-mail: mbenitov@sescam.jccm.es

Tfno: (+34) 925 247 774